Ioana Mârțu, Irina Georgeta Sufaru, Liliana Păsărin, Silvia MARTU, Sorina Mihaela Solomon
THE ROLE OF THE HOST MODULATION OF THE INFLAMMATORY RESPONSE AS AN ADJUNCTIVE PERIODONTAL TREATMENT
The concept of modulating the host response translates into modifying or regulating the harmful or destructive aspects of the host’s inflammatory response in the periodontal tissue that occurs as a result of chronic challenge of subgingival plaque. While studies on NSAIDs, bisphosphonates and, more recently, p38MAPK inhibitors, and rezolvine lipoxins, demonstrated beneficial effects, only sub-antimicrobial doses of doxycycline obtained the FDA approval. However, the clinical relevance of adjunct therapy benefits is still questioned. Further progress in this area expects better forms of disease classification and identification of the molecular basis for multi-faceted imbalances that cause inflammation. Resolvins have a positive effect on neutrophils in subjects with localized aggressive periodontitis; topical resolvind can reverse the periodontal inflammation in animal models with periodontal disease. Scientists are pinning their hopes in pharmacogenomics, where genetic and epigenetic changes of the the patient will modulate the host response by medication and even diet.