Oana Chipirliu, Mădălina Nicoleta Matei
Aim of the study Periodontitis is an inflammatory condition, caused by a dynamic interaction between the specific subgingival microbiome, the host’s immune response, exposure to certain environmental factors and genetic factors. The manifestations of periodontal diseases are not limited to local effects only. The specialized literature highlights significant associations between periodontitis and a series of systemic conditions, such as cardiovascular diseases. Periodontal diseases and cardiovascular diseases have an increased prevalence among the modern population and the identification of a causal relationship between these two pathologies could be of particular importance. This study represents a theoretical research, in medical databases, with the aim of highlighting the complex relationship between periodontal and cardiovascular diseases. Periodontal pathogenic microorganisms can disseminate in the general circulation, triggering a state of bacteremia, in systemically susceptible people (for example, patients with cardiovascular diseases). Inflammation can connect periodontal diseases to systemic, cardiovascular disorders by increasing systemic inflammatory markers and acute phase reactants, due to the production of proinflammatory cytokines at the level of periodontal lesions.