Romanian Journal of Medical and Dental Education Volum 13 Issue 1, 2024 THE IMPACT OF GUT MICROBIOTA ON RECURRENT APHTHOUS STOMATITIS


Mihaela Paula Toader, Oana Mihaela Condurache Hritcu, Cristina Popa, Ana Maria Sciuca, Bianca Andreea Onofrei, Stefan Vasile Toader


Recurrent Aphthous Stomatitis (RAS) is a prevalent oral mucosal disorder characterized by recurring painful ulcers. The pathogenesis of RAS remains incompletely understood, but emerging evidence suggests a significant link between gut microbiota and the development of RAS. This review aims to explore the existing literature on the interplay between gut microbiota and RAS, focusing on how intestinal dysbiosis may influence the onset and severity of RAS. We discuss the role of gut microbiota in immune modulation, the breakdown of oral tolerance, and the possible pathways through which gut bacteria can affect oral health. Additionally, we examine the impact of diet, antibiotics, and probiotics on the gut microbiota and, subsequently, on RAS. The review concludes with potential therapeutic strategies targeting gut microbiota to manage and prevent RAS, paving the way for novel interventions in this field.

Loader Loading...
EAD Logo Taking too long?

Reload Reload document
| Open Open in new tab

Download [178.75 KB]