Romanian Journal of Medical and Dental Education Volum 10 Issue 1, 2021 IN-VITRO STUDY ON STRUCTURAL CHANGES IN TYPE I COLLAGEN AS A RESULT OF EXPOSURE TO ORAL CAVITY CONDITIONS

IN-VITRO STUDY ON STRUCTURAL CHANGES IN TYPE I COLLAGEN AS A RESULT OF EXPOSURE TO ORAL CAVITY CONDITIONS

Alexandru Vlasa, Csilla Bukhari, Bucur Sorana Maria, Anamaria Bud, Luminița Lazăr, Krisztina Martha, Gabriel G.Condurache,  Mariana Păcurar, Eugen Bud

Abstract

In the field of periodontal surgery, tissue grafting is generally used to accelerate the healing of bone defects, especially in the case of relatively large defects. The aim of this study was to analyze possible structural, topographic or mechanical changes of an allograft Type I collagen product, Condress  ™, in an artificially constructed environment that simulates the conditions of the oral cavity. The study samples were divided into the study group represented by immersion in freshly collected blood and 5 control groups represented by different immersion solutions. The fastest collagen resorption rate was observed in preparations introduced into hydrogen peroxide. On the other hand, a marked expansion of the material was observed in the preparations introduced into the glucose solution. The allograft collagen used in the present study was completely resorbed within approximately 10 to 14 days of immersion in the artificially created solutions.

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