George-Alexandru Maftei, Maria-Alexandra Martu, Ana-Maria Sciuca, Ioanina Mihaela Parlatescu, Cristina Popa
Worldwide the rate of edentulism due to an increasingly aging population is as high as 70%, according to region, country, socio-ecconomic status, etc. The habit of using a removable prosthesis, can alter the delicate ecological balance of the oral cavity can cause denture candidiasis. Chronic atrophic candidiasis, or denture candidiasis, is a common infection of the oral cavity caused by overgrowth of mainly Candida species and it affects mostly patients with an affected immune system. Risk factors for the development of this pathology can be divided in two, systemic or local. Drugs like steroids, broad spectrum antibiotics, immunosuppressives can increase the risk of oral candidiasis by suppressing cellular immunity and phagocytosis.
Timely diagnosis of the ethiopathogenic pathogenic fungal microorganisms and the susceptibility to antifungal medication are crucial to the correct treatment of the infection and to implement preventive healthcare-associated strategies. Mirroring bacterial resistance, fungal infections, both non-Candida albicans but also antifungal resistant isolates have up-surged; thus, reliable diagnostic methods and new treatment modalities (utilizing novel antifungal agents or alternative therapies such as photodisinfection) are much sought-after in the management of candidiasis.