Loredana Liliana Hurjui, Ion Hurjui, Cristina Claudia Tărniceriu, Mihaela Mitrea, Andrei Ion Hurjui, Ruxandra Maria Hârțan, Diana Popovici, Carina Balcoș,Oana Adina Armencia, Irina Grădinaru
The oral cavity represents an area access zone from the external environment to the internal areas of the body and saliva is at the interface between microbial ecosystems and oral immune cells. Any imbalance of saliva physiology has an impact on oral and systemic health. Elevated inflammatory cytokines in saliva, for example, activates dysbiosis (disease) of periodontal tissues, feeding forward tissue inflammation, leading to oral tissue loss. Host–microbiome interactions complex modulate pathological transitions including gingivitis, periodontal diseases, and oral cancer. However, mechanisms involving these interactions are poorly understood at the molecular level.